What is Lorazepam

Lorazepam is a medication that belongs to a group of drugs known as Benzodiazepin. It is sold under the brand name Ativan among others.

Benzodiazepine (Benzos) is a family of psychoactive drugs. They operate on the nervous system causing a change in mood, cognition, behavior, or perception. Similar to other Benzos, Ativan acts quickly on the central nervous system by increasing the availability of gamma-aminobutyric acid (GABA) to the brain. 

It is scheduled as a Schedule IV drug under the Controlled Substances Act in the U.S. and internationally under the United Nations Convention on Psychotropic Substances. This means that the drug comes with a low potential for abuse and low risk of dependence and is medically beneficial. Lorazepam was first introduced by Wyeth Pharmaceuticals in 1977 and has been since a very common prescription for the treatment of several health issues. In terms of medical use, Benzos are one of the most verschriebene Medikamente in der Welt. Laut IQVIA ™ wurden in den USA 45,0 Millionen Alprazolam-, 26,4 Millionen Lorazepam-, 29,2 Millionen Clonazepam-, 12,6 Millionen Diazepam- und 7,0 Millionen Temazepam-Rezepte verschrieben

Generally, Lorazepam is effective in treating symptoms of anxiety disorders such as including panic attacks, unjustified fears, sleeplessness, agitation, and restlessness. It is best prescribed as a short term treatment to prevent any complications. It can also help with status epilepticus (continuous seizures). Lorazepam is sometimes used as a sedative for individuals receiving mechanical ventilation.

Despite the positives of the medical uses, Lorazepam can cause several side effects, especially when abused recreationally. Benzos such as Ativan can create desirable and euphoric effects which leads to non-medical use.

 

Lorazepam Side Effects

Ativan may cause serious side effects including:

  • severe drowsiness,
  • thoughts of suicide or hurting yourself,
  • unusual changes in mood or behaviour,
  • confusion,
  • aggression,
  • hallucinations,
  • worsened sleep problems,
  • sudden restless feeling or excitement,
  • muscle weakness,
  • drooping eyelids,
  • trouble swallowing,
  • vision changes,
  • upper stomach pain,
  • dark urine, and
  • yellowing of the skin or eyes (jaundice)

With long-term benzodiazepine use, it is unclear whether cognitive impairments completely recovers to regular after quitting lorazepam use; cognitive deficiencies continue for at least six months after withdrawal, and sometimes even longer. The higher the doses the more severe the effects are. These effects can include respiratory depression and CNS problems. High doses can also lead to physical and psychological dependency especially when used for longer than 4 weeks. The high potency and short half-life of Ativan can increase the chances of dependency. A person who abuses Ativan or is dependent on the drug tries to get prescriptions from several doctors and might even forge ones themselves. Others might steal medicine from other people. In many cases, people obtain their Benzos from illegal sources who smuggle the drugs. In 2017, there were 47,546 alprazolam, 11,430 clonazepam, 4,451 diazepams, 2,315 lorazepam, and 236 temazepam reports from federal, state, and local forensic Laboratories. For 2018, preliminary estimates indicate there were 40,035 alprazolam, 9,900 clonazepam, 3,421 diazepams, 1,901 lorazepam and 204 temazepam reports from Federal, state and local forensic laboratories.

 

Lorazepam Withdrawal – Lorazepam and Alcohol Addiction

With regular use, tolerance to the drug is developed and higher doses are required to experience the desired relief. In cases of dependence, abrupt quitting of the dug can lead to withdrawal symptoms. The most frequent symptoms of Rückzug von Benzodiazepinen sind:

 Die weniger häufigen Auswirkungen sind Reizbarkeit,

  • Schwitzen
  • Depersonalization
  • Derealisation
  • Überempfindlichkeit gegen Reize
  • Depression
  • Suicidal behaviour
  • Psychose
  • Anfälle
  • Delirium tremens

Symptoms and signs of lorazepam withdrawal typically climax two to four days after quitting the drug and can last up to a week.

 

Lorazepam Overdose Drug

Lorazepam abuse can also lead to an overdose which is generally not fatal unless Lorazepam is mixed with other opioids or Alkohol.

In mild cases, symptoms include drowsiness, mental confusion, paradoxical reactions, dysarthria and lethargy. In more serious cases, and especially when other drugs or alcohol were ingested, symptoms may include ataxia, hypotonia, hypotension, cardiovascular depression, respiratory depression, hypnotic state, coma, and death. In a Studie Basierend auf 6.148 Fällen gab es geschätzte 212.770 (95% CI = 167.163, 258.377) Notaufnahmen, die jährlich auf unerwünschte Ereignisse mit Benzodiazepinen zurückgeführt wurden. Mehr als die Hälfte waren Besuche, bei denen Benzodiazepine nicht medizinisch angewendet wurden (119.008; 55,9%, 95% CI = 50,0%, 61,9%).

In 2019, 16 per cent of overdose deaths involving opioids also involved benzodiazepines. There also reports of self-harm and suicidal tendencies among Benzo abusers. These numbers demonstrate the dangers of Benzos despite their stature. Even when prescribed medically they can still cause complications and lead to dependency. Recent years have seen an increase in illicit use of Benzos as demonstrated by the increased rates of trafficking and smuggling. In the United States, Lorapezam is considered to be among the top ten prescription medicines that are diverted from the licit market. 

For a safe recovery from using Lorazepam, medical supervision is advised to help the individual with a gradual reduction of the dosage. Medications can also help in relieving withdrawal physical side effects such as pains and agitation. If you need help with Benzodiazepine addiction, have a look at our Webseite. The dangers of Medikamentenmissbrauch und Sucht sind ständig auf dem Vormarsch. Menschen sind oft durch psychische und psychische Probleme belastet und neigen daher dazu, Substanzen zu missbrauchen, die ihre Schmerzen lindern könnten. Diese Substanzen können jedoch größere Gesundheitsprobleme verursachen und sogar zum Tod führen.

 

Verweise

Brunton L, Hilal-Dandan R, Knollmann B, Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 13th ed. McGraw-Hill, New York, NY2018

https://doi.org/10.15585/mmwr.rr6501e1er

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Shorter E (2005). “Benzodiazepines”. A Historical Dictionary of Psychiatry. Oxford University Press. pp. 41–2. ISBN 978-0-19-517668-1.

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